Vol 9, No 5 (2013)
Review paper
Published online: 2013-12-03
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Positron emission tomography in oncology with use of radiotracers alternative to 18F-fluorodeoxyglucose

Edyta Szurowska, Jacek Teodorczyk, Katarzyna Dziadziuszko, Joanna Pieńkowska, Grzegorz Romanowicz, Piotr Lass
Onkol. Prak. Klin 2013;9(5):197-199.

Abstract

The objective of the article is to present of clinically most relevant oncological applications of positron emission tomography with use of radiotracers alternative to 18F-fluorodeoxyglucose. These studies are applied with increasing frequency also in the case of lesions demonstrating low, insufficient for imaging uptake of glucose-basedradiotracer. 18F-fluorodeoxyglucose positron emission tomography allows assessment of metabolic rate in many frequently occurring neoplasms. In case of low-level or highly variable 18F-fluorodeoxyglucose uptake alternative radiotracers must be used. Clinically most relevant are isotopically labeled amino acids, nucleic acids components, cell membrane components or Krebs cycle substrates. Radiotracers alternative to 18F-fluorodeoxyglucose enable also evaluation of functional parameters other than metabolic such as e.g. receptor density or hypoxia level.

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