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Vol 47, No 3 (2009)
Original paper
Submitted: 2011-12-19
Published online: 2010-02-19
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Expression of tissue inhibitors of metalloproteinase 1 (TIMP-1) in gastric cancer tissue.

Barbara Mroczko, Marta Lukaszewicz-Zajac, Magdalena Groblewska, Jolanta Czyzewska, Mariusz Gryko, Katarzyna Guzińska-Ustymowicz, Andrzej Kemona, Bogusław Kedra, Maciej Szmitkowski
DOI: 10.2478/v10042-009-0071-6
·
Folia Histochem Cytobiol 2009;47(3):511-516.

open access

Vol 47, No 3 (2009)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2010-02-19

Abstract

Degradation of extracellular matrix (ECM) is an essential step of invasion and metastasis of gastric cancer. The proteolysis of basement membranes depends on the balance between activities of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The aim of the study was to assess the expression of TIMP-1 in gastric cancer (GC) and interstitial inflammatory infiltrate cells within GC tissue in relation to clinico-pathological features of tumor and to estimate the prognostic significance of TIMP-1 expression for patients' survival. The presence of TIMP-1 in 54 cases of gastric cancer samples was investigated by immunohistochemistry. The expression of TIMP-1 in cancer and interstitial inflammatory infiltrate cells was evaluated in semi-quantitative scale. The immunoreactivity of TIMP-1 in cancer and inflammatory cells was positive in 100% of cases and varied from weak to intense reaction. The intensity of TIMP-1 expression increased with more advanced tumor stages and in patients who died of cancer during 2-year observation. TIMP-1 expression in interstitial inflammatory infiltrate cells was the independent prognostic factor for patients' survival. The results suggest the role of TIMP-1 in gastric tumorigenesis, although this issue requires further investigtions.

Abstract

Degradation of extracellular matrix (ECM) is an essential step of invasion and metastasis of gastric cancer. The proteolysis of basement membranes depends on the balance between activities of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The aim of the study was to assess the expression of TIMP-1 in gastric cancer (GC) and interstitial inflammatory infiltrate cells within GC tissue in relation to clinico-pathological features of tumor and to estimate the prognostic significance of TIMP-1 expression for patients' survival. The presence of TIMP-1 in 54 cases of gastric cancer samples was investigated by immunohistochemistry. The expression of TIMP-1 in cancer and interstitial inflammatory infiltrate cells was evaluated in semi-quantitative scale. The immunoreactivity of TIMP-1 in cancer and inflammatory cells was positive in 100% of cases and varied from weak to intense reaction. The intensity of TIMP-1 expression increased with more advanced tumor stages and in patients who died of cancer during 2-year observation. TIMP-1 expression in interstitial inflammatory infiltrate cells was the independent prognostic factor for patients' survival. The results suggest the role of TIMP-1 in gastric tumorigenesis, although this issue requires further investigtions.

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About this article
Title

Expression of tissue inhibitors of metalloproteinase 1 (TIMP-1) in gastric cancer tissue.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 47, No 3 (2009)

Article type

Original paper

Pages

511-516

Published online

2010-02-19

Page views

2078

Article views/downloads

1989

DOI

10.2478/v10042-009-0071-6

Bibliographic record

Folia Histochem Cytobiol 2009;47(3):511-516.

Authors

Barbara Mroczko
Marta Lukaszewicz-Zajac
Magdalena Groblewska
Jolanta Czyzewska
Mariusz Gryko
Katarzyna Guzińska-Ustymowicz
Andrzej Kemona
Bogusław Kedra
Maciej Szmitkowski

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