Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.

Bozena Dobrzycka; Slawomir J Terlikowski; Piotr S Bernaczyk; Magdalena Garbowicz; Jacek Niklinski; Lech Chyczewski; Marek Kulikowski

doi:10.2478/v10042-010-0091-2

Vol 48, No 4 (2010)

Original paper

Submitted: 2011-12-19

Published online: 2011-04-12

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Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.

Bozena Dobrzycka, Slawomir J Terlikowski, Piotr S Bernaczyk, Magdalena Garbowicz, Jacek Niklinski, Lech Chyczewski, Marek Kulikowski

DOI: 10.2478/v10042-010-0091-2

Folia Histochem Cytobiol 2010;48(4):678-681.

Vol 48, No 4 (2010)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2011-04-12

Abstract

Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign.