open access

Vol 1, No 2 (2013)
Original article
Published online: 2013-12-27
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Evaluation of serum heat shock protein 70 concentration in women with recurrent miscarriages

Lena Nowak-Los, Grazyna Odrowaz-Sypniewska, Jacek Michalkiewicz, Izabela Kubiszewska, Jolanta Zegarska, Marta Zalewska-Zacharek
Folia Medica Copernicana 2013;1(2):58-61.

open access

Vol 1, No 2 (2013)
ORIGINAL ARTICLES
Published online: 2013-12-27

Abstract

Background. Heat shock proteins (Hsp) were discovered over 50 years ago and are commonly called ‘stress proteins’. Hsp proteins play an important role in a cell, in that they provide protection against cellstress factors and environmentally negative factors. The most conservative, and the best known, heat shock proteins are Hsp 70 subfamily proteins. It has been suggested that an increase of Hsp 70 in the blood during pregnancy has a negative impact. The aetiology of recurrent miscarriages in more than 60% of women remains unexplained. Therefore the aim of this study was to evaluate the usefulness of Hsp 70 assessment in the diagnosis of recurrent miscarriages.

Material and methods. The study group consisted of 100 women (aged 36.0 ± 4.9 years) who had experienced repeated miscarriages. The reference group consisted of 60 women (aged 36.1 ± 3.6 years), who had been pregnant at least twice and who had given birth by a spontaneous labour without complications. Hsp 70 was determined in the serum.

Results. We found no significant differences in the Hsp 70 concentration between the women with recurrent miscarriages and the reference group. While median serum Hsp 70 was the most elevated in the women with the highest number of miscarriages, this difference was not significant.

Conclusion. Based on the obtained results, it is difficult to determine whether Hsp 70 plays a causative role in recurrent miscarriages. However, taking into account the fact that the role of Hsp 70 in the course of normal and pathological pregnancy is not yet completely understood, it may be worth expanding the study to include a larger group of women with recurrent miscarriages.

Abstract

Background. Heat shock proteins (Hsp) were discovered over 50 years ago and are commonly called ‘stress proteins’. Hsp proteins play an important role in a cell, in that they provide protection against cellstress factors and environmentally negative factors. The most conservative, and the best known, heat shock proteins are Hsp 70 subfamily proteins. It has been suggested that an increase of Hsp 70 in the blood during pregnancy has a negative impact. The aetiology of recurrent miscarriages in more than 60% of women remains unexplained. Therefore the aim of this study was to evaluate the usefulness of Hsp 70 assessment in the diagnosis of recurrent miscarriages.

Material and methods. The study group consisted of 100 women (aged 36.0 ± 4.9 years) who had experienced repeated miscarriages. The reference group consisted of 60 women (aged 36.1 ± 3.6 years), who had been pregnant at least twice and who had given birth by a spontaneous labour without complications. Hsp 70 was determined in the serum.

Results. We found no significant differences in the Hsp 70 concentration between the women with recurrent miscarriages and the reference group. While median serum Hsp 70 was the most elevated in the women with the highest number of miscarriages, this difference was not significant.

Conclusion. Based on the obtained results, it is difficult to determine whether Hsp 70 plays a causative role in recurrent miscarriages. However, taking into account the fact that the role of Hsp 70 in the course of normal and pathological pregnancy is not yet completely understood, it may be worth expanding the study to include a larger group of women with recurrent miscarriages.

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Keywords

recurrent pregnancy loss, heat shock protein (Hsp 70)

About this article
Title

Evaluation of serum heat shock protein 70 concentration in women with recurrent miscarriages

Journal

Medical Research Journal

Issue

Vol 1, No 2 (2013)

Article type

Original article

Pages

58-61

Published online

2013-12-27

Page views

974

Article views/downloads

1678

Bibliographic record

Folia Medica Copernicana 2013;1(2):58-61.

Keywords

recurrent pregnancy loss
heat shock protein (Hsp 70)

Authors

Lena Nowak-Los
Grazyna Odrowaz-Sypniewska
Jacek Michalkiewicz
Izabela Kubiszewska
Jolanta Zegarska
Marta Zalewska-Zacharek

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