CD163 and its role in inflammation

Krzysztof Kowal; Richard Silver; Emila Sławińska; Marek Bielecki; Lech Chyczewski; Otylia Kowal-Bielecka

doi:10.5603/FHC.2011.0052

Vol 49, No 3 (2011)

Review paper

Submitted: 2012-01-05

Published online: 2011-10-28

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CD163 and its role in inflammation

Krzysztof Kowal, Richard Silver, Emila Sławińska, Marek Bielecki, Lech Chyczewski, Otylia Kowal-Bielecka

DOI: 10.5603/FHC.2011.0052

Folia Histochem Cytobiol 2011;49(3):365-374.

Vol 49, No 3 (2011)

REVIEW

Submitted: 2012-01-05

Published online: 2011-10-28

Abstract

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response. It seems, therefore, that CD163 may be an interesting target for therapeutic modulation of the inflammatory response. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 365–374)

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Keywords

CD163; inflammation

About this article

Title

CD163 and its role in inflammation

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 3 (2011)

Article type

Review paper

Pages

365-374

Published online

2011-10-28

Page views

5661

Article views/downloads

6710

DOI

10.5603/FHC.2011.0052

Bibliographic record

Folia Histochem Cytobiol 2011;49(3):365-374.

Keywords

CD163
inflammation

Authors

Krzysztof Kowal
Richard Silver
Emila Sławińska
Marek Bielecki
Lech Chyczewski
Otylia Kowal-Bielecka