open access

Vol 42, No 4 (2004)
Original paper
Submitted: 2011-12-19
Published online: 2005-02-12
Get Citation

Heterogeneity of extraparenchymal primitive neuroectodermal tumors within the craniospinal axis.

E Izycka-Swieszewska, W Kloc, K Plata-Nazar, J Stefanowicz, E Drozyńska, A Woźniak, D Gasecki, M Debiec-Rychter
Folia Histochem Cytobiol 2004;42(4):229-234.

open access

Vol 42, No 4 (2004)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2005-02-12

Abstract

Four cases of primitive neuroectodermal tumors (PNETs) with unusual localization (three intraspinal extramedullary and one pontocerebellar) are reviewed. Histologically, they were small round blue cell tumors with diverse patterns. Immunohistochemically, all tumors were positive for at least two neuronal markers, two cases were Mic-2 positive and one showed glial differentiation. The paraffin-embedded tumor specimens were examined by interphase FISH using dual-color probes specific for EWS, HER-2 and BCR loci. Molecular cytogenetic study revealed the presence of EWS rearrangement in two cases and the presence of i(17q) in one tumor. Three tumors exhibited 22 disomy and one was 22 polyploid. Extraparenchymal PNETs within craniospinal axis are heterogeneous from the clinical, histological, immunohistochemical and molecular point of view. These PNETs can be of a central or peripheral type. Multidisciplinary approach is of a basic importance in differential diagnosis of such cases.

Abstract

Four cases of primitive neuroectodermal tumors (PNETs) with unusual localization (three intraspinal extramedullary and one pontocerebellar) are reviewed. Histologically, they were small round blue cell tumors with diverse patterns. Immunohistochemically, all tumors were positive for at least two neuronal markers, two cases were Mic-2 positive and one showed glial differentiation. The paraffin-embedded tumor specimens were examined by interphase FISH using dual-color probes specific for EWS, HER-2 and BCR loci. Molecular cytogenetic study revealed the presence of EWS rearrangement in two cases and the presence of i(17q) in one tumor. Three tumors exhibited 22 disomy and one was 22 polyploid. Extraparenchymal PNETs within craniospinal axis are heterogeneous from the clinical, histological, immunohistochemical and molecular point of view. These PNETs can be of a central or peripheral type. Multidisciplinary approach is of a basic importance in differential diagnosis of such cases.
Get Citation
About this article
Title

Heterogeneity of extraparenchymal primitive neuroectodermal tumors within the craniospinal axis.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 42, No 4 (2004)

Article type

Original paper

Pages

229-234

Published online

2005-02-12

Page views

1021

Article views/downloads

1010

Bibliographic record

Folia Histochem Cytobiol 2004;42(4):229-234.

Authors

E Izycka-Swieszewska
W Kloc
K Plata-Nazar
J Stefanowicz
E Drozyńska
A Woźniak
D Gasecki
M Debiec-Rychter

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl