Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation.

Anna Pryczynicz; Katarzyna Guzińska-Ustymowicz; Violetta Dymicka-Piekarska; Jolanta Czyzewska; Andrzej Kemona

Vol 45, No 1 (2007)

Original paper

Submitted: 2011-12-19

Published online: 2007-03-24

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Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation.

Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz, Violetta Dymicka-Piekarska, Jolanta Czyzewska, Andrzej Kemona

Folia Histochem Cytobiol 2007;45(1):37-40.

Vol 45, No 1 (2007)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2007-03-24

Abstract

The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters. The study group consisted of 36 patients with pancreatic ductal carcinoma. Tumors were stained using immunohistochemical method (NCL -MMP-9, Novocastra). No correlation was found between tumor MMP-9 expression and age, gender or grade of histological malignancy. However, statistical analysis revealed a relationship between tumor MMP-9 expression and histological type (adenocarcinoma mucinosum) of pancreatic carcinoma. The expression was strongly correlated with lymph node involvement and occurrence of distant metastases (p<0.00001). The results indicate a correlation between the expression of MMP-9 in pancreatic ductal carcinoma and worse prognosis (shown by lymph node involvement and distant metastases).