Vol 45, Supp. I (2007)
Original paper
Submitted: 2011-12-19
Published online: 2008-04-15
Comparative study of the effects of pre and post natal administration of a thyroid drug on testicular activity in adult rat.
Z Hamouli-Said, F Tahari, F Hamoudi, F Hadj-Bekkouche
Vol 45, Supp. I (2007)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2008-04-15
Abstract
Thyroid hormone is known to play a critical role in growth and development of rat testes with a specific effect on the differentiation of Sertoli cells leading to a normal evolution of germ cells. In the present study, we aimed to compare the effect of induced hypothyroidism during fetal and post-natal life on the structure and function of the testis in adult. Pregnant or lactating mothers were treated with 6-propyl-2-thiouracil (PTU) during 21 days and weight gain of pups was steady until adult age. Plasma hormonal levels were determined by RIA and morphology of testis was studied on sections stained with Masson's trichrome. Pre and early post natal hypothyroidism resulted in an impairment of body development and a diminution of thyroid hormone levels of treated rats. No significant effect on testicular development has been observed when hypothyroidism is induced in fetal life while it was associated with reduction in testis weight, diameter of seminiferous tubules and hormonal levels and delay in maturation of germ cells, when induced during early post natal life.
Abstract
Thyroid hormone is known to play a critical role in growth and development of rat testes with a specific effect on the differentiation of Sertoli cells leading to a normal evolution of germ cells. In the present study, we aimed to compare the effect of induced hypothyroidism during fetal and post-natal life on the structure and function of the testis in adult. Pregnant or lactating mothers were treated with 6-propyl-2-thiouracil (PTU) during 21 days and weight gain of pups was steady until adult age. Plasma hormonal levels were determined by RIA and morphology of testis was studied on sections stained with Masson's trichrome. Pre and early post natal hypothyroidism resulted in an impairment of body development and a diminution of thyroid hormone levels of treated rats. No significant effect on testicular development has been observed when hypothyroidism is induced in fetal life while it was associated with reduction in testis weight, diameter of seminiferous tubules and hormonal levels and delay in maturation of germ cells, when induced during early post natal life.
Title
Comparative study of the effects of pre and post natal administration of a thyroid drug on testicular activity in adult rat.
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 45, Supp. I (2007)
Article type
Original paper
Pages
51-57
Published online
2008-04-15
Page views
1078
Article views/downloads
1582
Authors
Z Hamouli-Said
F Tahari
F Hamoudi
F Hadj-Bekkouche
About this article