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Vol 46, No 2 (2008)
Original paper
Submitted: 2011-12-19
Published online: 2008-06-04
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Dendritic cells based immunotherapy of patient with chondrosarcoma--case report.

Jacek Tabarkiewicz, Sebastian Radej, Iwona Hus, Magdalena Wasiak, Paulina Wdowiak, Krzysztof Giannopoulos, Beata Piechnik, Adam Kłos, Anna Dmoszyńska, Jacek Rolinski
DOI: 10.2478/v10042-008-0025-4
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Folia Histochem Cytobiol 2008;46(2):165-170.

open access

Vol 46, No 2 (2008)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2008-06-04

Abstract

We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.

Abstract

We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.

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About this article
Title

Dendritic cells based immunotherapy of patient with chondrosarcoma--case report.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 46, No 2 (2008)

Article type

Original paper

Pages

165-170

Published online

2008-06-04

Page views

2759

Article views/downloads

1951

DOI

10.2478/v10042-008-0025-4

Bibliographic record

Folia Histochem Cytobiol 2008;46(2):165-170.

Authors

Jacek Tabarkiewicz
Sebastian Radej
Iwona Hus
Magdalena Wasiak
Paulina Wdowiak
Krzysztof Giannopoulos
Beata Piechnik
Adam Kłos
Anna Dmoszyńska
Jacek Rolinski

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