Pathological findings in cornea tissue of patients with penetrating keratoplasty.

Helga KostelnĂĄ; JĂĄn Rosocha; Edita PaulĂ­ kovĂĄ; Igor KozĂĄk; MĂĄria AntalovĂĄ; Martin Mahel; Denisa HarvanovĂĄ; JozefĂ­na PetrovicovĂĄ; Ladislav BobĂĄk

doi:10.2478/v10042-010-0002-6

Vol 48, No 2 (2010)

Original paper

Submitted: 2011-12-19

Published online: 2010-08-03

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Pathological findings in cornea tissue of patients with penetrating keratoplasty.

Helga KostelnĂĄ, JĂĄn Rosocha, Edita PaulĂ kovĂĄ, Igor KozĂĄk, MĂĄria AntalovĂĄ, Martin Mahel, Denisa HarvanovĂĄ, JozefĂna PetrovicovĂĄ, Ladislav BobĂĄk

DOI: 10.2478/v10042-010-0002-6

Folia Histochem Cytobiol 2010;48(2):267-272.

Vol 48, No 2 (2010)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2010-08-03

Abstract

The aim of this clinical study was to examine corneas extracted from the patients during penetrating keratoplasty for the presence of immunoglobulins and inflammatory cells that can be warning for the graft failure. Individual clinical diagnoses were correlated to the presence of the inflammatory signs in corneal tissue. The signs of inflammation in corneal layers were detected especially in group of patients classified as viral keratitis but were also found in corneas of patients with degenerative diseases of the cornea. Depending on the number of keratoplasties no statistical difference in analysed parameters was found. Inflammatory process represented by slight positive presence cellular infiltration and/or immunoglobulins could be present in corneal tissue also in absence of acute manifestation. Histological and immunohistochemical evaluation of corneal tissue from patients undergoing penetrating keratoplasty could improve estimation of correct diagnosis. Subsequently prompt adequate therapy could improve worse prognosis of corneal graft with evident immune process.