Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.

Ewa Anna Kosakowska; Rafał Stec; Radosław Charkiewicz; Marta Skoczek; Lech Chyczewski

doi:10.2478/v10042-010-0078-z

Vol 48, No 4 (2010)

Original paper

Submitted: 2011-12-19

Published online: 2011-04-12

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Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.

Ewa Anna Kosakowska, Rafał Stec, Radosław Charkiewicz, Marta Skoczek, Lech Chyczewski

DOI: 10.2478/v10042-010-0078-z

Folia Histochem Cytobiol 2010;48(4):597-602.

Vol 48, No 4 (2010)

ORIGINAL PAPERS

Submitted: 2011-12-19

Published online: 2011-04-12

Abstract

In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.