open access
Effect of heavy metal cations on the activity of cathepsin D (in vitro study)
open access
Abstract
cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l. Hemoglobin
was the cathepsin D substrate. The activity of cathepsin D was determined at pH 3.5. Only Hg2+ cations
inhibit the activity of cathepsin D. Cations Hg2+ damage lysosomes and release cathepsin D from these organelles.
Abstract
cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l. Hemoglobin
was the cathepsin D substrate. The activity of cathepsin D was determined at pH 3.5. Only Hg2+ cations
inhibit the activity of cathepsin D. Cations Hg2+ damage lysosomes and release cathepsin D from these organelles.
Title
Effect of heavy metal cations on the activity of cathepsin D (in vitro study)
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
432-435
Published online
2012-10-08
Page views
2006
Article views/downloads
1957
DOI
10.5603/FHC.2012.0059
Bibliographic record
Folia Histochem Cytobiol 2012;50(3):432-435.
Authors
Alicja Karwowska
Radosław Łapiński
Marek Gacko
Ewa Grzegorczyk
Joanna Żurawska
Jan K. Karczewski