Occurrence of the  aacA4  gene among multidrug resistant strains of  Pseudomonas aeruginosa  isolated from bronchial secretions obtained from the Intensive Therapy Unit at University Hospital in Bialystok, Poland

Paweł Sacha; Jadwiga Jaworowska; Dominika Ojdana; Piotr Wieczorek; Sławomir Czaban; Elżbieta Tryniszewska

doi:10.5603/FHC.2012.0043

Vol 50, No 2 (2012)

Brief communication

Submitted: 2012-07-05

Accepted: 2012-07-05

Published online: 2012-07-05

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Occurrence of the aacA4 gene among multidrug resistant strains of Pseudomonas aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit at University Hospital in Bialystok, Poland

Paweł Sacha, Jadwiga Jaworowska, Dominika Ojdana, Piotr Wieczorek, Sławomir Czaban, Elżbieta Tryniszewska

DOI: 10.5603/FHC.2012.0043

Folia Histochem Cytobiol 2012;50(2):322-324.

Vol 50, No 2 (2012)

Short Communication

Submitted: 2012-07-05

Accepted: 2012-07-05

Published online: 2012-07-05

Abstract

The aim of this study was to investigate the prevalence of the aacA4 gene in a population of multidrug resistant strains of P. aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit (ITU). Twelve MDR isolates were tested for antibiotic susceptibility and the presence of the aacA4 gene. In this study, 58.3% of the strains contained (6’)-Ib’ aminoglycoside acetyltransferase gene. All of the studied strains (aacA4-positive and aacA4-negative) were susceptible only to colistine (100%). Among other antibiotics, the lowest resistance rates were those shown against ceftazidime (14.3% to 20%) and imipenem (28.6% to 40%). Our studies frequently revealed the presence of the aacA4 gene as a factor responsible for resistance; it is probable that other mechanisms of resistance to aminoglycoside antibiotics also occurred.

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Keywords

Pseudomonas aeruginosa; aacA4 gene; antimicrobial susceptibility

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Title

Occurrence of the aacA4 gene among multidrug resistant strains of Pseudomonas aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit at University Hospital in Bialystok, Poland

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 2 (2012)

Article type

Brief communication

Pages

322-324

Published online

2012-07-05

Page views

1988

Article views/downloads

2021

DOI

10.5603/FHC.2012.0043

Bibliographic record

Folia Histochem Cytobiol 2012;50(2):322-324.

Keywords

Pseudomonas aeruginosa
aacA4 gene
antimicrobial susceptibility

Authors

Paweł Sacha
Jadwiga Jaworowska
Dominika Ojdana
Piotr Wieczorek
Sławomir Czaban
Elżbieta Tryniszewska