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Vol 50, No 2 (2012)
Review paper
Submitted: 2012-07-04
Accepted: 2012-07-04
Published online: 2012-07-05
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Biochemical markers of psoriasis as a metabolic disease

Agnieszka Gerkowicz, Aldona Pietrzak, Jacek Cezary Szepietowski, Sebastian Radej, Grażyna Chodorowska
DOI: 10.5603/FHC.2012.0025
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Folia Histochem Cytobiol 2012;50(2):155-170.

open access

Vol 50, No 2 (2012)
REVIEW
Submitted: 2012-07-04
Accepted: 2012-07-04
Published online: 2012-07-05

Abstract

Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2–3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

Abstract

Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2–3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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Keywords

psoriasis; metabolic syndrome; adipokines; cytokines; uric acid; CRP; PAI-1

About this article
Title

Biochemical markers of psoriasis as a metabolic disease

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 2 (2012)

Article type

Review paper

Pages

155-170

Published online

2012-07-05

Page views

4850

Article views/downloads

6788

DOI

10.5603/FHC.2012.0025

Bibliographic record

Folia Histochem Cytobiol 2012;50(2):155-170.

Keywords

psoriasis
metabolic syndrome
adipokines
cytokines
uric acid
CRP
PAI-1

Authors

Agnieszka Gerkowicz
Aldona Pietrzak
Jacek Cezary Szepietowski
Sebastian Radej
Grażyna Chodorowska

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